Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.57 |
| ▸ | CDK9 | P50750 | 8/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.57 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 8/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.52 |
| ▸ | CCNK | O75909 | 2/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19112174 | 0.91 | CDK2 (0.58) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL19112253 | 0.88 | CDK2 (0.71) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL29326802 | 0.81 | CDK2 (0.56) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL15940645 | 0.81 | CDK2 (0.79) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL3389347 | 0.79 | CDK1 (0.68) | CDK2CCNA2CCNA1DYRK1ACDK5 | |
| SCHEMBL19112166 | 0.79 | CDK2 (0.72) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL7889584 | 0.78 | CDK2 (0.82) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL19112176 | 0.77 | CDK2 (0.61) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL19112097 | 0.75 | CDK2 (0.75) | CDK2CCNA2CCNA1CDK9DYRK1A | |
| SCHEMBL19111955 | 0.75 | CDK2 (0.75) | CDK2CCNA2CCNA1CDK9DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2664619-B1 | Purine derivatives as tools for screening anti-Alzheimer compounds | MANROS THERAPEUTICS (FR) | 2017-07-12 | — | — | EP | disclosed |