Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20392775 | 0.75 | MAOA (0.36) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL12712111 | 0.72 | MAOA (0.38) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL15932773 | 0.72 | MAOA (0.38) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL22450601 | 0.71 | MAOA (0.36) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL14432256 | 0.71 | MAOA (0.36) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL11068390 | 0.65 | — | — | |
| SCHEMBL8342845 | 0.63 | MAOA (0.36) | MAOAMAOBDRD1DRD3DRD2 | |
| SCHEMBL23465758 | 0.61 | — | — | |
| SCHEMBL18278112 | 0.61 | — | — | |
| SCHEMBL15157450 | 0.60 | MAOA (0.38) | MAOAMAOBDRD1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2664619-B1 | Purine derivatives as tools for screening anti-Alzheimer compounds | MANROS THERAPEUTICS (FR) | 2017-07-12 | — | — | EP | disclosed |