Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | FABP7 | O15540 | 1/20 | 0.49 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12489242 | 1.00 | POLB (0.56) | POLBSMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12686737 | 1.00 | POLB (0.56) | POLBSMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19113373 | 0.83 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12488726 | 0.82 | EDNRA (0.62) | POLBSMN1; SMN2FABP7FABP5EDNRA | |
| SCHEMBL12686733 | 0.82 | EDNRA (0.62) | POLBSMN1; SMN2FABP7FABP5EDNRA | |
| SCHEMBL8067771 | 0.80 | POLB (0.82) | POLBSLC6A4SLC6A3FABP7FABP5 | |
| SCHEMBL8067775 | 0.80 | POLB (0.82) | POLBSLC6A4SLC6A3FABP7FABP5 | |
| SCHEMBL16104896 | 0.78 | POLB (0.62) | POLBSLC6A3ALDH1A1TSHRTP53 | |
| SCHEMBL19397276 | 0.78 | POLB (0.62) | POLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19355164 | 0.76 | POLB (0.89) | POLBSLC6A3FABP7FABP5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3190108-A1 | HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS | 3-V Biosciences, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |