Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.51 |
| ▸ | CACNA1I | Q9P0X4 | 6/20 | 0.51 |
| ▸ | CCR3 | P51677 | 2/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056382 | 0.92 | CCR3 (0.48) | KCNH2CACNA1ICCR3CYP2C9CYP2C19 | |
| SCHEMBL19112971 | 0.86 | CACNA1I (0.64) | KCNH2CACNA1ICACNA1HCYP2D6LMNA | |
| SCHEMBL19113153 | 0.85 | KDM4E (0.51) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL16459142 | 0.85 | KCNH2 (0.56) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL4276834 | 0.83 | KCNH2 (0.52) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL4275627 | 0.83 | KCNH2 (0.55) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL4275154 | 0.81 | KCNH2 (0.52) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL4272474 | 0.78 | KCNH2 (0.55) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL19113045 | 0.77 | CARM1 (0.56) | KCNH2CACNA1ICCR3CYP2C9CYP2C19 | |
| SCHEMBL4271586 | 0.77 | KCNH2 (0.52) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |