Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.56 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.56 |
| ▸ | CCR3 | P51677 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275627 | 0.90 | KCNH2 (0.55) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL4275154 | 0.86 | KCNH2 (0.52) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL4276834 | 0.85 | KCNH2 (0.52) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL4272474 | 0.85 | KCNH2 (0.55) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL19112976 | 0.85 | KCNH2 (0.51) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL4271586 | 0.84 | KCNH2 (0.52) | KCNH2CACNA1ICCR3KDM4EPKM | |
| SCHEMBL19113052 | 0.83 | CYP2C9 (0.61) | KCNH2CACNA1ICCR3CYP2D6DRD4 | |
| SCHEMBL19113045 | 0.82 | CARM1 (0.56) | KCNH2CACNA1ICCR3CYP2C9CYP2C19 | |
| SCHEMBL4276648 | 0.82 | KCNH2 (0.52) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 | |
| SCHEMBL19112804 | 0.81 | KCNH2 (0.53) | KCNH2CACNA1ICCR3CACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140011996-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2014-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011996-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1H, CACNA1B | KCNH2 60/4885CACNA1I 4/4885CCR3 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.