Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283497 | 0.93 | KMT2A (0.42) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL89057 | 0.90 | REN (0.43) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL1911381 | 0.90 | KMT2A (0.40) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL2084329 | 0.88 | REN (0.42) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL90060 | 0.87 | REN (0.48) | RENKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL89822 | 0.87 | REN (0.44) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL1911409 | 0.87 | REN (0.44) | RENKMT2AMEN1HPGDNPSR1 | |
| SCHEMBL8236774 | 0.87 | REN (0.43) | RENKMT2AMEN1HPGDPOLB | |
| SCHEMBL89215 | 0.87 | REN (0.43) | RENKMT2AMEN1HPGDPOLB | |
| SCHEMBL90216 | 0.87 | REN (0.43) | RENKMT2AMEN1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |