Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89693 | 0.89 | REN (0.53) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL90127 | 0.85 | REN (0.54) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL89236 | 0.84 | REN (0.53) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL90137 | 0.84 | REN (0.54) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL89766 | 0.83 | REN (0.62) | RENALDH1A1POLBSMN1; SMN2KCNH2 | |
| SCHEMBL89763 | 0.83 | REN (0.52) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL90141 | 0.83 | REN (0.54) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL89116 | 0.83 | REN (0.54) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL89080 | 0.83 | REN (0.51) | RENALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL89598 | 0.83 | REN (0.52) | RENALDH1A1POLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |