Pyrilamine

Pyrilamine

SCHEMBL19114

COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

HRH1

The experimentally established mechanism targets of Pyrilamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 known ✓ P35367 3/20 1.00
LMNA P02545 4/20 1.00
CHRM2 P08172 4/20 1.00
ADRA2A P08913 4/20 1.00
DRD1 P21728 4/20 1.00
SLC6A4 P31645 4/20 1.00
SLC6A3 Q01959 4/20 1.00
KCNH2 Q12809 4/20 1.00
CYP2D6 P10635 4/20 1.00
HTR2A P28223 3/20 1.00
CYP1A2 P05177 3/20 1.00
OPRM1 P35372 3/20 1.00
CYP2C19 P33261 3/20 1.00
TSHR P16473 2/20 1.00
ALDH1A1 P00352 2/20 1.00
HTR2C P28335 2/20 1.00
HTR2B P41595 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP3A4 P08684 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrilamine SCHEMBL29444024 1.00 LMNA (1.00) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL22118219 0.99 LMNA (0.97) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL28823277 0.99 LMNA (0.97) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL4891045 0.99 LMNA (0.97) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL28350675 0.99 LMNA (0.97) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL28086659 0.97 LMNA (0.95) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL622845 0.97 LMNA (0.95) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL4075657 0.95 LMNA (0.90) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL4450392 0.93 CHRM2 (0.86) LMNACHRM2ADRA2ADRD1SLC6A4
Pyrilamine SCHEMBL28032666 0.93 LMNA (0.86) LMNACHRM2ADRA2ADRD1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 47225 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
CN-122023162-A Underwater image cross-domain enhancement method based on unsupervised UCycleGAN 湖南科技大学 2026-05-12 CN claimed
EP-4731194-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP Technologies, Inc. (US) 2026-04-29 EP claimed
EP-4691492-A2 LIQUID COMPOSITIONS Kenvue Brands LLC (US) 2026-02-11 EP claimed
US-12519131-B2 Polymer blend gel electrolytes GM Global Technology Operations LLC (US) 2026-01-06 US claimed
WO-2025264260-A1 MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT CSP TECHNOLOGIES, INC. (US) 2025-12-26 WO claimed
EP-4658703-A1 BIODEGRADABLE COMPOUNDS, METHOD OF PREPARATION AND USE THEREOF Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860) (IN) 2025-12-10 EP claimed
EP-4638444-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE Bristol-Myers Squibb Company (US) 2025-10-29 EP claimed
EP-4630401-A2 CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF Rutgers, the State University of New Jersey (US) 2025-10-15 EP claimed
EP-4247331-B1 ORODISPERSIBLE POWDER COMPOSITION COMPRISING AN ANTIHISTAMINE COMPOUND BIOPHARMA SYNERGIES S L (ES) 2025-10-08 EP claimed
EP-0000065-A1 Process and apparatus for bundling rods, tubes, profiles, and other oblong objects kabelmetal Messingwerke GmbH (DE) 1978-12-20 EP claimed
US-4118496-A HISTAMINE H2-ANTAGONISTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-10-03 US claimed
US-RE29761-E INHIBITORS OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-09-12 US claimed
US-4109003-A N-(IMIDAZOLYL-METHYLTHIO-ALKYL) DERIVATIVES OF S-ALKYL ISOTHIOUREAS; ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-22 US claimed
US-4107319-A GUANIDINES, BLOCKING AGENTS SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-15 US claimed
US-4104382-A (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4104381-A HISTAMINE INHIBITORS, ((IMIDAZOLYLALKYL)AMINO)THIADIAZINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1978-08-01 US claimed
US-4005205-A PYRIMIDINE COMPOUNDS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-01-25 US claimed
US-4000302-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-12-28 US claimed
US-3981398-A Aid in the management of clinical emergencies in medical and dental practices and other circumstances Pienaar, Hendrik Lukas (ZA) 1976-09-21 US claimed