Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2811991 | 0.83 | REN (1.00) | REN | |
| SCHEMBL13131426 | 0.83 | REN (1.00) | REN | |
| Hydrochloric Acid SCHEMBL2806005 | 0.83 | REN (0.98) | REN | |
| SCHEMBL13131839 | 0.81 | REN (0.96) | REN | |
| SCHEMBL13625727 | 0.81 | REN (0.68) | RENKCNH2 | |
| SCHEMBL90365 | 0.80 | REN (0.69) | RENKCNH2 | |
| SCHEMBL13131545 | 0.79 | REN (0.73) | REN | |
| SCHEMBL13131556 | 0.79 | REN (0.73) | REN | |
| SCHEMBL13625565 | 0.78 | REN (0.64) | RENKCNH2 | |
| SCHEMBL90497 | 0.78 | REN (0.66) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |