Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 6/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911420 | 0.89 | REN (0.49) | RENPDE4BLMNAMEN1KMT2A | |
| SCHEMBL13131884 | 0.85 | REN (0.64) | RENPDE4BNR1H4 | |
| SCHEMBL2810181 | 0.85 | REN (0.64) | RENPDE4BNR1H4 | |
| SCHEMBL13448644 | 0.83 | REN (0.42) | RENMEN1KMT2AALDH1A1BCL9 | |
| SCHEMBL89732 | 0.82 | REN (0.53) | RENPDE4BMEN1KMT2AALDH1A1 | |
| SCHEMBL2808955 | 0.82 | REN (0.57) | RENPDE4BNR1H4 | |
| SCHEMBL13132227 | 0.82 | REN (0.57) | RENPDE4BNR1H4 | |
| SCHEMBL13132505 | 0.82 | REN (0.57) | RENPDE4BNR1H4 | |
| SCHEMBL89310 | 0.80 | REN (0.51) | RENPDE4BLMNAALDH1A1 | |
| SCHEMBL2814031 | 0.80 | REN (0.64) | RENLMNAMEN1KMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |