Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19118056 | 0.90 | PDE4B (0.60) | PDE4BGRIN2BMAPTTSHRRXFP1 | |
| SCHEMBL19118428 | 0.88 | PDE4B (0.55) | PDE4BMAPTNPSR1MEN1KMT2A | |
| SCHEMBL19119122 | 0.86 | PDE4B (0.51) | PDE4BTP53MAT2A | |
| SCHEMBL17784227 | 0.85 | PDE4B (0.54) | PDE4BRAB9A | |
| SCHEMBL17784221 | 0.84 | PDE4B (0.57) | PDE4BLMNAMAPK1HTTMAT2A | |
| SCHEMBL16446627 | 0.84 | PDE4B (0.50) | PDE4BTP53MAT2ARAB9A | |
| SCHEMBL19119085 | 0.83 | PDE4B (0.57) | PDE4BTP53MAT2ARAB9A | |
| SCHEMBL19119137 | 0.83 | PDE4B (0.49) | PDE4BTP53 | |
| SCHEMBL17784217 | 0.83 | PDE4B (0.60) | PDE4BGRIN2BMEN1KMT2A | |
| SCHEMBL19118430 | 0.82 | PDE4B (0.47) | PDE4BMAPTUSP2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030565-B1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |