Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.53 |
| ▸ | GPR52 | Q9Y2T5 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19119080 | 0.90 | PDE4B (0.65) | PDE4BGPR52DYRK1AGAAFFAR1 | |
| SCHEMBL19118465 | 0.83 | PDE4B (0.66) | PDE4BGAAPDE4DDGAT1KDM4E | |
| SCHEMBL19118463 | 0.81 | PDE4B (0.60) | PDE4BPDE4DDGAT1 | |
| SCHEMBL19118469 | 0.80 | PDE4B (0.54) | PDE4BKDM4EALDH1A1 | |
| SCHEMBL16446595 | 0.80 | PDE4B (0.66) | PDE4BGPR52PDE4D | |
| SCHEMBL16447019 | 0.80 | PDE4B (0.82) | PDE4BPDE4D | |
| SCHEMBL19119079 | 0.80 | PDE4B (0.71) | PDE4BPDE4D | |
| SCHEMBL19119118 | 0.79 | PDE4B (0.51) | PDE4BDYRK1AGAAFFAR1WNT1 | |
| SCHEMBL19118473 | 0.78 | PDE4B (0.54) | PDE4BGAAFFAR1PDE4DKDM4E | |
| SCHEMBL16446717 | 0.71 | PDE4B (0.75) | PDE4BGPR52PDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030565-B1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2017-07-19 | — | — | EP | disclosed |