Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 13/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353239 | 0.88 | ROCK2 (0.48) | ROCK1ROCK2ATG4BKDM4ENPC1 | |
| SCHEMBL19119209 | 0.85 | ROCK1 (0.48) | ROCK1ROCK2ATG4B | |
| SCHEMBL19119187 | 0.85 | ROCK1 (0.48) | ROCK1ROCK2ATG4BNAMPT | |
| SCHEMBL19119394 | 0.84 | ROCK1 (0.47) | ROCK1ROCK2ATG4BNAMPT | |
| SCHEMBL19119288 | 0.84 | ROCK1 (0.46) | ROCK1ROCK2ATG4BKDM4EALDH1A1 | |
| SCHEMBL19119102 | 0.83 | ROCK1 (0.48) | ROCK1ROCK2ATG4B | |
| SCHEMBL19119292 | 0.83 | ROCK2 (0.51) | ROCK1ROCK2ATG4BNAMPT | |
| SCHEMBL19119499 | 0.82 | ROCK1 (0.50) | ROCK1ROCK2ATG4B | |
| SCHEMBL19118736 | 0.82 | ROCK1 (0.48) | ROCK1ROCK2ATG4B | |
| SCHEMBL19119346 | 0.82 | ROCK1 (0.49) | ROCK1ROCK2ATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |