Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 11/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19120318 | 0.82 | GRM5 (0.50) | GRM5KCNH2CYP1A2 | |
| SCHEMBL19120416 | 0.77 | GRM5 (0.46) | GRM5TDP1L3MBTL1KCNH2CYP1A2 | |
| SCHEMBL19120270 | 0.76 | GRM5 (0.44) | GRM5TDP1L3MBTL1KCNH2CYP1A2 | |
| SCHEMBL19120571 | 0.74 | GRM5 (0.42) | GRM5KCNH2CYP1A2 | |
| Methyl Alcohol SCHEMBL28902013 | 0.70 | GRM5 (0.67) | GRM5L3MBTL1KCNH2CYP1A2 | |
| SCHEMBL352291 | 0.70 | GRM5 (0.65) | GRM5TDP1KCNH2CYP1A2 | |
| SCHEMBL27996721 | 0.67 | GRM5 (0.53) | GRM5KCNH2CYP1A2 | |
| SCHEMBL704827 | 0.66 | GRM5 (0.68) | GRM5TDP1L3MBTL1KCNH2 | |
| SCHEMBL20623471 | 0.66 | — | — | |
| SCHEMBL17347505 | 0.66 | ADK (0.49) | GRM5KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10941132-B2 | Pyrazole derivatives | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2021-03-09 | — | — | US | disclosed |
| US-20190002432-A1 | PYRAZOLE DERIVATIVES | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2019-01-03 | — | — | US | disclosed |
| WO-2017117708-A1 | PYRAZOLE DERIVATIVES | HUA MEDICINE (SHANGHAI) LTD. (CN) | 2017-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10941132-B2 | Pyrazole derivatives | GRM5, GRIK5, GRIN2C | GRM5 1/4885TDP1 2361/4885L3MBTL1 3222/4885 |
| US-20190002432-A1 | PYRAZOLE DERIVATIVES | GRM5, GRIK5, GRIN2C | GRM5 1/4885TDP1 2361/4885L3MBTL1 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.