Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 11/20 | 0.72 |
| ▸ | MAPK10 | P53779 | 11/20 | 0.72 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.72 |
| ▸ | INSR | P06213 | 3/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.60 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.60 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 3/20 | 0.58 |
| ▸ | CDC7 | O00311 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.58 |
| ▸ | PAK4 | O96013 | 2/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.58 |
| ▸ | CLK2 | P49760 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12729770 | 0.90 | PTK2 (0.58) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL12729763 | 0.88 | PTK2 (0.61) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL1912053 | 0.84 | ALK (0.60) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL1912009 | 0.84 | ALK (0.60) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL12893066 | 0.81 | AXL (0.62) | INSRIGF1REGFRCDK2ALK | |
| SCHEMBL12729777 | 0.81 | ALK (0.62) | INSRPTK2EGFRALKMET | |
| SCHEMBL12917664 | 0.80 | ULK1 (0.53) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL28589740 | 0.77 | EGFR (0.82) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL12729786 | 0.76 | ALK (0.57) | MAPK9MAPK10MAPK8INSRIGF1R | |
| SCHEMBL25668162 | 0.76 | EGFR (0.81) | MAPK9MAPK10MAPK8INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |