Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.58 |
| ▸ | ULK1 | O75385 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.54 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.54 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912003 | 0.92 | ALK (0.69) | ALKULK1EGFRIGF1RZAP70 | |
| SCHEMBL1912073 | 0.92 | ALK (0.60) | ALKULK1EGFRGSK3ALRRK2 | |
| SCHEMBL12780162 | 0.91 | ULK1 (0.71) | ALKULK1EGFRGSK3ALRRK2 | |
| SCHEMBL1912072 | 0.91 | ULK1 (0.71) | ALKULK1EGFRGSK3ACDC7 | |
| SCHEMBL1912028 | 0.91 | ALK (0.60) | ALKULK1EGFRGSK3ALRRK2 | |
| SCHEMBL12729257 | 0.89 | ALK (0.75) | ALKEGFRGSK3ACDC7PLK4 | |
| SCHEMBL1912026 | 0.85 | ZAP70 (0.64) | ALKULK1EGFRGSK3ALRRK2 | |
| SCHEMBL12781521 | 0.85 | ZAP70 (0.64) | ALKULK1EGFRGSK3ALRRK2 | |
| SCHEMBL382124 | 0.83 | ALK (0.81) | ALKULK1EGFRIGF1RZAP70 | |
| SCHEMBL12917965 | 0.83 | ULK1 (0.60) | ALKULK1EGFRGSK3ACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |