Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24477562 | 1.00 | SLC6A2 (0.49) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL9673258 | 1.00 | SLC6A2 (0.49) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| Hydrochloric Acid SCHEMBL23123360 | 0.98 | SLC6A2 (0.47) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL4202702 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL30368752 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL18019719 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL4202698 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL18019718 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL4202694 | 0.88 | SLC6A2 (0.52) | SLC6A2ADRA1AHTR2BSLC6A3CHRNB2 | |
| SCHEMBL9674560 | 0.83 | KDM1A (0.42) | SLC6A2HTR2BSLC6A3KDM1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170196862-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170196862-A2 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, SCNN1B, SLC26A4 | SLC6A2 1083/4885ADRA1A 620/4885HTR2B 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.