Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.58 |
| ▸ | TUBB | P07437 | 4/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.58 |
| ▸ | TNF | P01375 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20668088 | 0.90 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19126103 | 0.87 | TUBB1 (0.58) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19126079 | 0.85 | TUBB1 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14189657 | 0.81 | TNF (0.48) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL19100258 | 0.77 | TUBB1 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL12635184 | 0.77 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31687105 | 0.77 | TUBB1 (0.72) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL10304651 | 0.76 | PLAU (0.62) | TNF | |
| SCHEMBL19100041 | 0.76 | HDAC8 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL400167 | 0.75 | TNF (0.47) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3400210-B1 | \"MULTI-TARGET\" COMPOUNDS WITH INHIBITORY ACTIVITY TOWARDS HISTONE DEACETYLASES AND TUBULIN POLYMERISATION, FOR USE IN THE TREATMENT OF CANCER | UNIV PARIS SACLAY (FR) | 2021-09-29 | — | — | EP | disclosed |
| WO-2017118822-A2 | \"MULTI-TARGET\" COMPOUNDS WITH INHIBITORY ACTIVITY TOWARDS HISTONE DEACETYLASES AND TUBULIN POLYMERISATION, FOR USE IN THE TREATMENT OF CANCER | UNIVERSITE PARIS-SUD (FR) | 2017-07-13 | — | — | WO | disclosed |