Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 6/20 | 0.62 |
| ▸ | PLG | P00747 | 4/20 | 0.62 |
| ▸ | TNF | P01375 | 7/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14189657 | 0.88 | TNF (0.48) | PLAUPLGTNFCREBBP | |
| SCHEMBL400167 | 0.86 | TNF (0.47) | PLAUPLGTNFCREBBP | |
| SCHEMBL10113676 | 0.86 | TNF (0.47) | PLAUPLGTNFCREBBP | |
| SCHEMBL4473320 | 0.81 | TNF (0.53) | TNFCREBBP | |
| SCHEMBL20553630 | 0.80 | TNF (0.52) | TNFCREBBP | |
| SCHEMBL20668088 | 0.78 | TUBB1 (0.72) | TNF | |
| SCHEMBL403709 | 0.77 | TNF (0.49) | TNFCREBBP | |
| SCHEMBL9324289 | 0.77 | LMNA (0.61) | TNFCREBBP | |
| SCHEMBL19125573 | 0.76 | TUBB1 (0.58) | TNF | |
| SCHEMBL7417377 | 0.76 | MAPT (0.49) | TNFCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2206710-B1 | Indole derivatives as S1P1 receptor agonists | GLAXO GROUP LTD (GB) | 2012-07-04 | — | — | EP | disclosed |
| EP-2091949-B1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2011-05-18 | — | — | EP | disclosed |
| EP-2206710-A1 | Indole derivatives as S1P1 receptor agonists | Glaxo Group Limited (GB) | 2010-07-14 | — | — | EP | disclosed |