Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.52 |
| ▸ | CPA1 | P15085 | 2/20 | 0.51 |
| ▸ | CPB1 | P15086 | 1/20 | 0.51 |
| ▸ | CPA3 | P15088 | 1/20 | 0.51 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912637 | 1.00 | MME (0.53) | MMEFOLH1CPA1CPB1CPA3 | |
| SCHEMBL2807018 | 0.87 | MME (0.67) | MMECPA1CPB1CPA3CPB2 | |
| SCHEMBL30543817 | 0.77 | CYP1A2 (0.56) | MMEFOLH1CPA1CPB1CPA3 | |
| SCHEMBL2804430 | 0.73 | CPA1 (0.63) | MMECPA1CPB1CPA3CPB2 | |
| SCHEMBL6841478 | 0.73 | CYP1A2 (0.51) | MMEFOLH1CPA1CPA3ACE | |
| SCHEMBL5870627 | 0.73 | CYP1A2 (0.51) | MMEFOLH1CPA1CPA3ACE | |
| SCHEMBL9456007 | 0.73 | GRIA2 (0.57) | MMECPA1ACEKMT2AAOC3 | |
| SCHEMBL6684906 | 0.73 | FOLH1 (0.54) | MMEFOLH1CPA1CPA3ACE | |
| SCHEMBL5096045 | 0.72 | PTGS2 (0.51) | MMEFOLH1CPA1CPB1CPA3 | |
| SCHEMBL9554490 | 0.72 | CPA1 (0.60) | MMEFOLH1CPA1CPB1CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435409-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136493-A1 | SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2010-12-02 | — | — | WO | disclosed |