Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29735646 | 1.00 | HTT (0.54) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29735513 | 0.90 | NPC1 (0.59) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19127904 | 0.90 | NPC1 (0.59) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29735643 | 0.86 | HTT (0.57) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19127879 | 0.86 | HTT (0.57) | HTTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29735586 | 0.84 | NPC1 (0.52) | HTTALDH1A1SMN1; SMN2PDE4ANPC1 | |
| SCHEMBL29735588 | 0.84 | NPC1 (0.52) | HTTALDH1A1SMN1; SMN2PDE4ANPC1 | |
| SCHEMBL19128520 | 0.84 | NPC1 (0.52) | HTTALDH1A1SMN1; SMN2PDE4ANPC1 | |
| SCHEMBL24437306 | 0.81 | CNR1 (0.52) | HTTALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL24437193 | 0.79 | CNR1 (0.55) | HTTALDH1A1SMN1; SMN2CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602775-B | Mast cell modulators and uses thereof | 贝思以色列女会吏医学中心公司 | 2022-04-29 | — | — | CN | disclosed |
| US-11084789-B2 | Mast-cell modulators and uses thereof | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-11084789-B2 | Mast-cell modulators and uses thereof | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| US-20200148638-A1 | MAST-CELL MODULATORS AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2020-05-14 | — | — | US | disclosed |
| US-20190016680-A1 | MAST-CELL MODULATORS AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2019-01-17 | — | — | US | disclosed |
| US-20190016680-A1 | MAST-CELL MODULATORS AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2019-01-17 | — | — | US | disclosed |
| EP-3402780-A1 | MAST-CELL MODULATORS AND USES THEREOF | Beth Israel Deaconess Medical Center, Inc. (US) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017123826-A1 | MAST-CELL MODULATORS AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-07-20 | — | — | WO | disclosed |
| WO-2017123826-A1 | MAST-CELL MODULATORS AND USES THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11084789-B2 | Mast-cell modulators and uses thereof | KIT, CPA3, CMA1 | HTT 4602/4885ALDH1A1 1074/4885SMN1; SMN2 3936/4885 |
| US-20190016680-A1 | MAST-CELL MODULATORS AND USES THEREOF | KIT, CPA3, CMA1 | HTT 4600/4885ALDH1A1 1246/4885SMN1; SMN2 4037/4885 |
| US-20200148638-A1 | MAST-CELL MODULATORS AND USES THEREOF | KIT, CPA3, CMA1 | HTT 4602/4885ALDH1A1 1074/4885SMN1; SMN2 3936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.