CPA3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL393002	1.00	3/20
SCHEMBL1915564	1.00	3/20
SCHEMBL1719401	0.72	3/20
SCHEMBL638640	0.70	3/20
SCHEMBL1859177	0.70	3/20
SCHEMBL839261	0.68	3/20
SCHEMBL839262	0.68	3/20
SCHEMBL1114629	0.68	3/20
SCHEMBL1177225	0.68	3/20
SCHEMBL1915234	0.68	3/20
SCHEMBL1915237	0.68	3/20
SCHEMBL1915616	0.68	3/20
SCHEMBL1373606	0.66	3/20
Bromide (SCHEMBL1177352)	0.66	3/20
SCHEMBL265063	0.66	3/20
SCHEMBL265514	0.66	3/20
SCHEMBL491524	0.66	3/20
SCHEMBL558159	0.66	3/20
SCHEMBL429946	0.64	3/20
SCHEMBL1195866	0.63	3/20

Clinical trials — most relevant to CPA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients	PHASE2/PHASE3	COMPLETED
Effects of Anti-TSLP in Patients With Asthma	PHASE2	COMPLETED
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	PHASE2	COMPLETED
The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose	PHASE2	COMPLETED
Mast Cells in Male Pelvic Pain and and Lower Urinary Tract Dysfunction	EARLY_PHASE1	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing	nan	COMPLETED
Cause and Natural Course of Pediatric-Onset Mastocytosis	nan	COMPLETED
Mast Cells and Its Proteases in COPD	nan	UNKNOWN
Allergy and Immunology Natural History Study	nan	RECRUITING
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals	nan	COMPLETED
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation	nan	COMPLETED
Pathogenesis of Physical Induced Urticarial Syndromes	nan	COMPLETED
Cause of Unexplained Anaphylaxis	nan	ACTIVE_NOT_RECRUITING
Persistence of Sensitization to Contrast Media	nan	NOT_YET_RECRUITING
Serum Basal Tryptase Levels in Healthy Children	nan	COMPLETED
Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement	nan	UNKNOWN
Mast Cell Activation Test in Allergic Disease	nan	COMPLETED
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis	nan	COMPLETED
Effect of FODMAPs on Mucosal Inflammation in IBS Patients	nan	UNKNOWN
Cutaneous Mastocytosis in Children: Analysis of Somatic and Germline Mutations	nan	COMPLETED
Implications and Stability of Clinical and Molecular Phenotypes of Severe Asthma	nan	COMPLETED
Contribution of Nasal IgE Production to the Boost of Systemic Allergen-specific IgE Upon Nasal Allergen Contact	nan	RECRUITING
Are Mast Cells Involved in Autoinflammatory Diseases	nan	NOT_YET_RECRUITING
Diagnosis and Allergen Identification of Perioperative Anaphylaxis	nan	RECRUITING
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.	nan	RECRUITING
Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy	nan	COMPLETED
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).	nan	COMPLETED
GI Alpha-Gal Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CPA3 binder may also engage these)

Protein	Name	Similarity
Q9JHH6	—	0.998	Q9JHH6 →
CPA2	Carboxypeptidase A2	0.995	landscape →
P15089	—	0.995	P15089 →
P21961	—	0.993	P21961 →
Q9EQV9	—	0.991	Q9EQV9 →
Q0II73	—	0.991	Q0II73 →
Q2KIG3	—	0.990	Q2KIG3 →
B8JLQ9	—	0.990	B8JLQ9 →
P09955	—	0.989	P09955 →
P09954	—	0.988	P09954 →
Q8WXQ8	—	0.988	Q8WXQ8 →
P19223	—	0.988	P19223 →
CPA4	Carboxypeptidase A4	0.988	landscape →
CPB1	Carboxypeptidase B	0.987	landscape →
P38836	—	0.986	P38836 →
P00732	—	0.986	P00732 →
Q6P8K8	—	0.986	Q6P8K8 →
P55261	—	0.986	P55261 →
D4D675	—	0.984	D4D675 →
CPB2	Carboxypeptidase B2	0.984	landscape →
Q3T905	—	0.983	Q3T905 →
O02350	—	0.983	O02350 →
Q8R4H4	—	0.983	Q8R4H4 →
P37892	—	0.981	P37892 →
Q9VL86	—	0.981	Q9VL86 →
Q4R7R2	—	0.981	Q4R7R2 →
A0A1S4F020	—	0.981	A0A1S4F020 →
P00730	—	0.981	P00730 →
Q10916	—	0.981	Q10916 →
B6V865	—	0.981	B6V865 →