Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.38 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652738 | 0.85 | TSHR (0.58) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL648785 | 0.81 | TSHR (0.56) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL11095759 | 0.80 | TSHR (0.55) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL647960 | 0.80 | TSHR (0.55) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL650051 | 0.80 | TSHR (0.55) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1912781 | 0.79 | TSHR (0.50) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL1912780 | 0.77 | TSHR (0.51) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL649593 | 0.75 | TSHR (0.52) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL11092583 | 0.74 | TSHR (0.51) | TSHRHSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL6619406 | 0.74 | TSHR (0.58) | TSHRHSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |