Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649593 | 0.86 | TSHR (0.52) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL11098723 | 0.83 | CASR (0.47) | TSHRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL11095759 | 0.83 | TSHR (0.55) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL11166790 | 0.81 | ALDH1A1 (0.49) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL11100993 | 0.80 | TSHR (0.51) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL4769369 | 0.76 | TSHR (0.47) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL1912766 | 0.74 | TSHR (0.51) | TSHRKDM4EALDH1A1HPGDNR1H3 | |
| SCHEMBL11093753 | 0.73 | AGTR1 (0.56) | — | |
| SCHEMBL11166001 | 0.73 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDTP53TLR7 | |
| SCHEMBL11096714 | 0.73 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028833-B1 | IMIDAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-01-25 | — | — | EP | disclosed |
| US-4340598-A | Hypotensive imidazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-07-20 | — | — | US | disclosed |
| EP-0028833-A2 | Imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1981-05-20 | — | — | EP | disclosed |