Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912784 | 0.88 | SMN1; SMN2 (0.51) | HSD11B1TSHRSMN1; SMN2POLBNPSR1 | |
| SCHEMBL23398972 | 0.82 | SMN1; SMN2 (0.47) | HSD11B1TSHRSMN1; SMN2POLBNPSR1 | |
| SCHEMBL23398696 | 0.79 | HSD11B1 (0.43) | HSD11B1TSHRSMN1; SMN2NR1H3MAPT | |
| SCHEMBL16381208 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL23398949 | 0.74 | RECQL (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDCASP1 | |
| SCHEMBL1912785 | 0.74 | CYP1A2 (0.50) | SMN1; SMN2ALDH1A1HPGDATMHSD17B10 | |
| SCHEMBL11708100 | 0.74 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2ALDH1A1KDM4ECASP1 | |
| SCHEMBL23398563 | 0.74 | ESR1 (0.47) | HSD11B1TSHRCASP1CASP7NR1H3 | |
| SCHEMBL23400892 | 0.74 | MEN1 (0.51) | HSD11B1TSHRKDM4ECASP1CASP7 | |
| SCHEMBL23399565 | 0.73 | HSD11B1 (0.47) | HSD11B1TSHRALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |