Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.65 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.65 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.65 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.65 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.65 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.65 |
| ▸ | RORC | P51449 | 13/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19129009 | 0.90 | PSEN1 (0.78) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL25904036 | 0.88 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19129012 | 0.85 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19128925 | 0.79 | RORC (0.76) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19129007 | 0.77 | RORC (0.97) | RORCNR1I2 | |
| SCHEMBL16880335 | 0.76 | RORC (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22662799 | 0.75 | RORC (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22662775 | 0.75 | RORC (0.84) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16891685 | 0.75 | RORC (1.00) | RORCNR1I2 | |
| SCHEMBL19129018 | 0.73 | RORC (0.85) | RORCNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708253-B2 | Cyclohexyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708253-B2 | Cyclohexyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |