Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 10/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912906 | 1.00 | C5AR1 (0.39) | C5AR1CXCR3TSHRKDM4EALDH1A1 | |
| SCHEMBL650465 | 0.90 | C5AR1 (0.40) | C5AR1CXCR3TSHRKDM4EALDH1A1 | |
| SCHEMBL1912913 | 0.90 | C5AR1 (0.40) | C5AR1CXCR3TSHRKDM4EALDH1A1 | |
| SCHEMBL651973 | 0.85 | C5AR1 (0.39) | C5AR1CXCR3ADORA1 | |
| SCHEMBL647784 | 0.85 | C5AR1 (0.39) | C5AR1CXCR3ADORA1 | |
| SCHEMBL648933 | 0.85 | C5AR1 (0.59) | C5AR1CXCR3ALDH1A1 | |
| SCHEMBL1912894 | 0.85 | C5AR1 (0.59) | C5AR1CXCR3ALDH1A1 | |
| SCHEMBL649705 | 0.84 | C5AR1 (0.38) | C5AR1TSHRKDM4EALDH1A1CYP3A4 | |
| SCHEMBL5134524 | 0.83 | C5AR1 (0.46) | C5AR1CXCR3 | |
| SCHEMBL1912900 | 0.83 | C5AR1 (0.46) | C5AR1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |