Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 7/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647784 | 1.00 | C5AR1 (0.39) | C5AR1UBE2MDCUN1D1ADORA1TRPV4 | |
| SCHEMBL649169 | 0.91 | C5AR1 (0.40) | C5AR1UBE2MDCUN1D1ADORA1TRPV4 | |
| SCHEMBL647842 | 0.91 | C5AR1 (0.40) | C5AR1UBE2MDCUN1D1ADORA1TRPV4 | |
| SCHEMBL1912906 | 0.85 | C5AR1 (0.39) | C5AR1ADORA1CXCR3 | |
| SCHEMBL1912904 | 0.85 | C5AR1 (0.39) | C5AR1ADORA1CXCR3 | |
| SCHEMBL648933 | 0.84 | C5AR1 (0.59) | C5AR1UBE2MDCUN1D1CXCR3PKM | |
| SCHEMBL1912894 | 0.84 | C5AR1 (0.59) | C5AR1UBE2MDCUN1D1CXCR3PKM | |
| SCHEMBL649705 | 0.83 | C5AR1 (0.38) | C5AR1 | |
| SCHEMBL652022 | 0.83 | C5AR1 (0.59) | C5AR1UBE2MDCUN1D1TRPV4 | |
| SCHEMBL648119 | 0.83 | C5AR1 (0.59) | C5AR1UBE2MDCUN1D1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |