Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17446082 | 0.94 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17446139 | 0.90 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL19130180 | 0.83 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17446072 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17446076 | 0.79 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL28010239 | 0.76 | TSHR (0.61) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 | |
| SCHEMBL17446219 | 0.76 | ALDH1A1 (0.82) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL2821098 | 0.74 | NPC1 (0.93) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17446255 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL17446081 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170202818-A1 | METHODS AND COMPOSITIONS TO MODIFY GSK-3 ACTIVITY | OHIO UNIVERSITY (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170202818-A1 | METHODS AND COMPOSITIONS TO MODIFY GSK-3 ACTIVITY | OHIO UNIVERSITY (US) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202818-A1 | METHODS AND COMPOSITIONS TO MODIFY GSK-3 ACTIVITY | GSK3B, GSK3A, GSKIP | ALDH1A1 4476/4885KDM4E 2378/4885HPGD 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.