⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19153645 | 0.81 | SOAT1 (0.35) | — | |
| SCHEMBL5474776 | 0.78 | — | — | |
| SCHEMBL19705865 | 0.74 | MEN1 (0.31) | — | |
| SCHEMBL984694 | 0.71 | — | — | |
| SCHEMBL125606 | 0.71 | KMT2A (0.48) | — | |
| SCHEMBL15336996 | 0.70 | KDM4E (0.36) | — | |
| SCHEMBL2854532 | 0.70 | — | — | |
| SCHEMBL25293609 | 0.68 | KMT2A (0.52) | — | |
| SCHEMBL252458 | 0.68 | KMT2A (0.46) | — | |
| SCHEMBL727151 | 0.68 | KMT2A (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931407-B2 | Silicon based drug conjugates and methods of using same | BLINKBIO, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| WO-2017214491-A1 | SILANOL BASED THERAPEUTIC PAYLOADS | BLINKBIO, INC. (US) | 2017-12-14 | — | — | WO | disclosed |
| US-20170202970-A1 | SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME | BLINKBIO, INC. | 2017-07-20 | — | — | US | disclosed |
| US-20170202970-A1 | SILICON BASED DRUG CONJUGATES AND METHODS OF USING SAME | BLINKBIO, INC. | 2017-07-20 | — | — | US | disclosed |