Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19614040 | 1.00 | JAK2 (0.45) | JAK2JAK1GAASCN1ASCN8A | |
| SCHEMBL19133453 | 1.00 | JAK2 (0.45) | JAK2JAK1GAASCN1ASCN8A | |
| SCHEMBL19613995 | 0.81 | DRD4 (0.44) | SCN1ASCN8ASIGMAR1FUCA1MEN1 | |
| SCHEMBL19613994 | 0.81 | DRD4 (0.44) | SCN1ASCN8ASIGMAR1FUCA1MEN1 | |
| SCHEMBL9057155 | 0.81 | MEN1 (0.46) | GAASIGMAR1FUCA1CXCR3ACHE | |
| SCHEMBL9057157 | 0.81 | MEN1 (0.46) | GAASIGMAR1FUCA1CXCR3ACHE | |
| SCHEMBL12167511 | 0.80 | ACHE (0.49) | JAK2JAK1GAASIGMAR1FUCA1 | |
| SCHEMBL14302494 | 0.80 | ACHE (0.49) | JAK2JAK1GAASIGMAR1FUCA1 | |
| SCHEMBL31598442 | 0.79 | NPY2R (0.42) | JAK2JAK1GAASCN1ASCN8A | |
| SCHEMBL1189631 | 0.79 | JAK2 (0.56) | JAK2JAK1GAASCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10081635-B2 | Substituted N-(pyrrolidine-3-yl)-7H-pyrrolo[2,3-D]pyrimidine-4-amine as janus kinase inhibitor | YANG JI CHEMICAL CO., LTD. (KR) | 2018-09-25 | — | — | US | disclosed |
| US-20170283421-A1 | SUBSTITUTED N-(PYRROLIDINE-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE AS JANUS KINASE INHIBITOR | YANG JI CHEMICAL CO., LTD. (KR) | 2017-10-05 | — | — | US | disclosed |
| EP-3196199-A2 | SUBSTITUTED N-(PYRROLIDINE-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE AS JANUS KINASE INHIBITOR | Yang Ji Chemical Co., Ltd. (KR) | 2017-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283421-A1 | SUBSTITUTED N-(PYRROLIDINE-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE AS JANUS KINASE INHIBITOR | JAK3, JAK2, JAK1 | JAK2 2/4885JAK1 3/4885GAA 3894/4885 |
| US-10081635-B2 | Substituted N-(pyrrolidine-3-yl)-7H-pyrrolo[2,3-D]pyrimidine-4-amine as janus kinase inhibitor | JAK3, JAK2, JAK1 | JAK2 2/4885JAK1 3/4885GAA 3894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.