Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1914437 | 0.94 | HDAC11 (0.47) | HDAC11LMNAKDM4EHDAC2PTGS2 | |
| SCHEMBL14974246 | 0.94 | HDAC11 (0.47) | HDAC11LMNAKDM4EHDAC2PTGS2 | |
| SCHEMBL13505425 | 0.91 | HDAC11 (0.52) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL1913848 | 0.85 | RARB (0.49) | HDAC11KDM4EHDAC2ALDH1A1ESR1 | |
| SCHEMBL13505438 | 0.85 | HDAC11 (0.58) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL1914161 | 0.85 | HDAC11 (0.49) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL2391025 | 0.83 | HDAC11 (0.50) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL1914344 | 0.83 | XDH (0.40) | HDAC11LMNAKDM4EALDH1A1IKBKB | |
| SCHEMBL1913918 | 0.83 | HDAC11 (0.45) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL2389089 | 0.82 | HDAC11 (0.47) | HDAC11LMNAKDM4EHDAC2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079305-A1 | THERAPEUTIC COMPOUNDS | WAYNE STATE UNIVERSITY (US) | 2011-06-30 | — | — | WO | disclosed |