Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 12/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1915335 | 0.83 | PDPK1 (0.48) | PDPK1MAPK1ALK | |
| SCHEMBL1915483 | 0.79 | PDPK1 (0.61) | PDPK1MAPK1 | |
| SCHEMBL1915718 | 0.75 | PDPK1 (0.48) | PDPK1MAPK1ALK | |
| SCHEMBL1915407 | 0.75 | MAPK1 (0.49) | PDPK1MAPK1 | |
| SCHEMBL1915730 | 0.73 | PDPK1 (0.49) | PDPK1MAPK1 | |
| SCHEMBL1456792 | 0.72 | PDPK1 (0.62) | PDPK1PIK3CA | |
| SCHEMBL1456546 | 0.72 | PDPK1 (0.62) | PDPK1PIK3CA | |
| SCHEMBL1456993 | 0.71 | PDPK1 (0.63) | PDPK1PIK3CA | |
| SCHEMBL1456938 | 0.71 | PDPK1 (0.63) | PDPK1PIK3CA | |
| SCHEMBL1456069 | 0.71 | PDPK1 (0.63) | PDPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666544-B | Pyrrolo[2,3-d]pyrazin-7-yl pyrimidine compounds | MERCK PATENT GMBH | 2014-11-26 | — | — | CN | disclosed |
| EP-2516442-A1 | PYRROLO[2,3-D]PYRAZIN-7-YL PYRIMIDINE COMPOUNDS | Merck Patent GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| CN-102666544-A | Pyrrolo[2,3-d]pyrazin-7-yl pyrimidine compounds | MERCK PATENT GMBH | 2012-09-12 | — | — | CN | disclosed |
| WO-2011076327-A1 | PYRROLO[2,3-D]PYRAZIN-7-YL PYRIMIDINE COMPOUNDS | MERCK PATENT GMBH (DE) | 2011-06-30 | — | — | WO | disclosed |