Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 13/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1915335 | 0.91 | PDPK1 (0.48) | MAPK1PDPK1 | |
| SCHEMBL1915718 | 0.84 | PDPK1 (0.48) | MAPK1PDPK1 | |
| SCHEMBL1915730 | 0.80 | PDPK1 (0.49) | MAPK1PDPK1 | |
| SCHEMBL1915289 | 0.77 | MAPK1 (0.50) | MAPK1PDPK1 | |
| SCHEMBL1915207 | 0.75 | PDPK1 (0.46) | MAPK1PDPK1 | |
| SCHEMBL12531459 | 0.72 | MAPK1 (0.46) | MAPK1PDPK1 | |
| SCHEMBL12531468 | 0.72 | PDPK1 (0.53) | MAPK1PDPK1 | |
| SCHEMBL1914945 | 0.72 | MAPK1 (0.56) | MAPK1PDPK1 | |
| SCHEMBL1916381 | 0.72 | PDPK1 (0.53) | MAPK1PDPK1 | |
| SCHEMBL1915631 | 0.72 | PDPK1 (0.53) | MAPK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516442-A1 | PYRROLO[2,3-D]PYRAZIN-7-YL PYRIMIDINE COMPOUNDS | Merck Patent GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076327-A1 | PYRROLO[2,3-D]PYRAZIN-7-YL PYRIMIDINE COMPOUNDS | MERCK PATENT GMBH (DE) | 2011-06-30 | — | — | WO | disclosed |