Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 7/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 9/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4922149 | 0.77 | PDE4A (0.46) | PDE1APDE1BPDE4AP2RX7PDE5A | |
| SCHEMBL4916725 | 0.69 | PDE4A (0.56) | PDE1APDE1BPDE4AP2RX7PDE5A | |
| SCHEMBL19158342 | 0.65 | PDE1A (0.47) | PDE1APDE1BPDE4APDE5A | |
| SCHEMBL4919936 | 0.64 | PDE1A (0.56) | PDE1APDE1BPDE4APDE5APDE4B | |
| SCHEMBL20661654 | 0.62 | PDE4A (0.41) | PDE1APDE1BPDE4APDE5A | |
| SCHEMBL18380649 | 0.60 | PDE4A (0.45) | PDE1APDE1BPDE4APDE5A | |
| SCHEMBL4914890 | 0.60 | PDE4A (0.45) | PDE1APDE1BPDE4APDE5A | |
| SCHEMBL22096333 | 0.60 | PDE4A (0.50) | PDE1APDE1BPDE4APDE5APDE4B | |
| SCHEMBL4925794 | 0.60 | PDE1A (0.47) | PDE1APDE1BPDE4AP2RX7PDE5A | |
| SCHEMBL19158604 | 0.58 | PDE4A (0.36) | PDE1APDE1BPDE4AP2RX7PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888534-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2017-07-26 | — | — | EP | disclosed |