Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 7/20 | 0.47 |
| ▸ | PDE4A | P27815 | 12/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PDE8A | O60658 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916725 | 0.83 | PDE4A (0.56) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL18380649 | 0.77 | PDE4A (0.45) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL4914890 | 0.77 | PDE4A (0.45) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL22096333 | 0.71 | PDE4A (0.50) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL21144927 | 0.67 | PDE4A (0.51) | PDE4APDE2APDE8APDE5APDE3B | |
| SCHEMBL4922149 | 0.65 | PDE4A (0.46) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL4911681 | 0.65 | PDE4A (0.57) | PDE4APDE1BPDE2APDE8APDE5A | |
| SCHEMBL19158000 | 0.65 | PDE1A (0.36) | PDE1APDE4APDE1BPDE5A | |
| SCHEMBL22421693 | 0.64 | PDE1A (0.67) | PDE1APDE4APDE1BPDE2APDE8A | |
| SCHEMBL16036074 | 0.64 | PDE1A (1.00) | PDE1APDE4APDE1BPDE2APDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888534-B1 | ORGANIC COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2017-07-26 | — | — | EP | disclosed |