Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18468447 | 0.96 | POLB (0.38) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL16559855 | 0.96 | POLB (0.40) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL16559859 | 0.92 | POLB (0.43) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL16559843 | 0.92 | POLB (0.40) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL19159097 | 0.90 | AKR1C3 (0.41) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL24555444 | 0.90 | POLB (0.44) | POLBAPEX1HTTTDP1RARA | |
| SCHEMBL26044722 | 0.90 | POLB (0.44) | POLBAPEX1HTTTDP1RARA | |
| SCHEMBL19824585 | 0.90 | POLB (0.44) | POLBAPEX1HTTTDP1RARA | |
| SCHEMBL18468437 | 0.88 | POLB (0.44) | POLBAPEX1HTTTDP1PTGS2 | |
| SCHEMBL19158500 | 0.88 | POLB (0.44) | POLBAPEX1HTTTDP1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848676-B1 | Liquid crystal medium | MERCK PATENT GMBH (DE) | 2017-07-26 | — | — | EP | disclosed |