Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649496 | 0.95 | C5AR1 (0.44) | C5AR1TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL650270 | 0.91 | C5AR1 (0.43) | C5AR1TSHRLTB4R2ALDH1A1KDM4E | |
| SCHEMBL5135444 | 0.91 | C5AR1 (0.47) | C5AR1TSHRLTB4R2ALDH1A1KDM4E | |
| SCHEMBL5137880 | 0.88 | C5AR1 (0.45) | C5AR1TSHRLTB4R2ALDH1A1KDM4E | |
| SCHEMBL1915992 | 0.88 | BCHE (0.42) | C5AR1HPGD | |
| SCHEMBL5136942 | 0.87 | C5AR1 (0.46) | C5AR1TSHRLTB4R2ALDH1A1KDM4E | |
| SCHEMBL650123 | 0.87 | C5AR1 (0.39) | C5AR1TSHRALDH1A1KDM4EHRH3 | |
| SCHEMBL4766671 | 0.87 | C5AR1 (0.44) | C5AR1TSHRALDH1A1KDM4EHPGD | |
| SCHEMBL652163 | 0.85 | C5AR1 (0.64) | C5AR1TSHRALDH1A1HPGD | |
| SCHEMBL5136767 | 0.85 | C5AR1 (0.41) | C5AR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |