Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650089 | 0.93 | C5AR1 (0.37) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL5634119 | 0.89 | C5AR1 (0.43) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL651171 | 0.88 | C5AR1 (0.42) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL649431 | 0.86 | C5AR1 (0.44) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL648187 | 0.82 | C5AR1 (0.46) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL650859 | 0.81 | C5AR1 (0.51) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL649494 | 0.79 | C5AR1 (0.44) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL650039 | 0.79 | C5AR1 (0.49) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 | |
| SCHEMBL1913077 | 0.78 | CXCR3 (0.33) | ALDH1A1MAPK1OPRM1OPRD1SMN1; SMN2 | |
| SCHEMBL651442 | 0.78 | C5AR1 (0.47) | C5AR1ALDH1A1MAPK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |