Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577837 | 0.88 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTTP53POLBKMT2A | |
| SCHEMBL12989268 | 0.83 | MAPT (0.62) | LMNASMN1; SMN2MAPTTP53POLB | |
| SCHEMBL8931659 | 0.82 | KMT2A (0.65) | RXFP1LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL18856931 | 0.82 | FPR2 (0.61) | SMN1; SMN2MAPTPOLBKMT2AMEN1 | |
| SCHEMBL3568215 | 0.81 | KMT2A (1.00) | RXFP1LMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL15928333 | 0.80 | KMT2A (0.65) | RXFP1LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL8931649 | 0.80 | KMT2A (0.61) | RXFP1LMNASMN1; SMN2MAPTTP53 | |
| SCHEMBL10598972 | 0.79 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTKMT2AALDH1A1RAB9A | |
| SCHEMBL15800700 | 0.79 | KMT2A (0.72) | LMNASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL7454467 | 0.79 | KMT2A (0.72) | LMNASMN1; SMN2MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170209436-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170209436-A1 | ITRACONAZOLE ANALOGUES AND METHODS OF USE THEREOF | GLI1, SHH, SMO | RXFP1 2823/4885LMNA 4777/4885SMN1; SMN2 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.