Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 18/20 | 0.69 |
| ▸ | FPR2 | P25090 | 10/20 | 0.69 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11030944 | 1.00 | GRM5 (0.69) | GRM5FPR2P2RX7 | |
| SCHEMBL11952149 | 1.00 | GRM5 (0.69) | GRM5FPR2P2RX7 | |
| SCHEMBL11030578 | 1.00 | GRM5 (0.69) | GRM5FPR2P2RX7 | |
| SCHEMBL10151945 | 0.90 | GRM5 (0.83) | GRM5FPR2P2RX7 | |
| SCHEMBL11027572 | 0.85 | GRM5 (0.51) | GRM5FPR2 | |
| SCHEMBL19192049 | 0.85 | GRM5 (0.76) | GRM5FPR2P2RX7 | |
| SCHEMBL19192348 | 0.85 | GRM5 (0.76) | GRM5FPR2P2RX7 | |
| SCHEMBL11942861 | 0.84 | GRM5 (0.74) | GRM5FPR2P2RX7 | |
| SCHEMBL19193467 | 0.84 | GRM5 (0.74) | GRM5FPR2P2RX7 | |
| SCHEMBL11942860 | 0.84 | GRM5 (0.74) | GRM5FPR2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2654422-B1 | Bicyclo[3.2.1]octyl amide derivatives as allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5 or mGluR5) for the treatment of central nervous system (CNS) disorders | H LUNDBECK AS (DK) | 2017-08-02 | — | — | EP | disclosed |