Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19179183 | 0.94 | PRKCD (0.44) | MCL1PRKCDCAMK2BCAMK2GAURKB | |
| SCHEMBL4175161 | 0.91 | PRKCD (0.53) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19178556 | 0.87 | MCL1 (0.52) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19180683 | 0.87 | PRKCD (0.58) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19180473 | 0.85 | PRKCD (0.47) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL4154592 | 0.84 | PRKCD (0.54) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19178798 | 0.84 | MCL1 (0.52) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19178837 | 0.84 | PRKCD (0.61) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19178794 | 0.83 | MRGPRX4 (0.51) | ALBMCL1PRKCDCAMK2BCAMK2G | |
| SCHEMBL19178585 | 0.80 | MCL1 (0.45) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-B1 | 7-SUBSTITUTED INDOLE AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2017-08-02 | — | — | EP | claimed |