Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 9/20 | 0.52 |
| ▸ | ALB | P02768 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
| ▸ | NEK4 | P51957 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19178556 | 0.97 | MCL1 (0.52) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19180683 | 0.92 | PRKCD (0.58) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL4166877 | 0.91 | PRKCD (0.63) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL4164069 | 0.87 | PRKCD (0.64) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19180402 | 0.87 | PRKCD (0.57) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19180490 | 0.86 | PRKCD (0.58) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19180388 | 0.85 | PRKCD (0.56) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19179206 | 0.85 | PRKCD (0.56) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19178583 | 0.84 | ALB (0.45) | MCL1ALBPRKCDCAMK2BCAMK2G | |
| SCHEMBL19179211 | 0.83 | MCL1 (0.55) | MCL1ALBPRKCDCAMK2BCAMK2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134684-B1 | 7-SUBSTITUTED INDOLE AS MCL-1 INHIBITORS | ABBVIE INC (US) | 2017-08-02 | — | — | EP | claimed |