Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.38 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3514146 | 0.79 | SRC (0.52) | SRCLMNAKMT2ANPSR1ALOX5 | |
| Hydrochloric Acid SCHEMBL6647673 | 0.78 | SRC (0.50) | SRCLMNAKMT2AALDH1A1NPSR1 | |
| SCHEMBL9706850 | 0.77 | SRC (0.70) | SRCALDH1A1EPHX1PTPN1PTPN6 | |
| SCHEMBL4749781 | 0.77 | SRC (0.53) | SRCLMNANPSR1ALOX5EPHX1 | |
| SCHEMBL13619014 | 0.77 | SRC (0.70) | SRCALDH1A1EPHX1PTPN1PTPN6 | |
| SCHEMBL2517600 | 0.77 | MMP8 (0.51) | SRCLMNAKMT2AMAPT | |
| SCHEMBL16800002 | 0.77 | SRC (0.42) | SRCLMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL5133327 | 0.76 | SRC (0.48) | SRCLMNAKMT2AALDH1A1NPSR1 | |
| SCHEMBL5153770 | 0.76 | SRC (0.52) | SRCLMNANPSR1ALOX5EPHX1 | |
| Hydrochloric Acid SCHEMBL28043659 | 0.76 | SRC (0.52) | SRCLMNANPSR1ALOX5EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3408268-A1 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA | Vitae Pharmaceuticals, Inc. (US) | 2018-12-05 | — | — | EP | disclosed |
| WO-2017132432-A1 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA | VITAE PHARMACEUTICALS, INC. (US) | 2017-08-03 | — | — | WO | disclosed |