Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 5/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.33 |
| ▸ | BCHE | P06276 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855087 | 0.95 | TSHR (0.37) | TSHRDRD1HTR2AHTR2CHTR2B | |
| SCHEMBL30666837 | 0.95 | TSHR (0.37) | TSHRDRD1HTR2AHTR2CHTR2B | |
| SCHEMBL19827177 | 0.93 | TSHR (0.36) | TSHRHTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL929527 | 0.93 | TSHR (0.36) | TSHRHTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL14922866 | 0.93 | TSHR (0.36) | TSHRHTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL15428812 | 0.93 | TSHR (0.36) | TSHRHTR2AHTR2CHTR2BMAPK1 | |
| SCHEMBL14394512 | 0.79 | TSHR (0.32) | TSHROPRK1POLBRXFP1 | |
| SCHEMBL1013730 | 0.77 | HTR2C (0.38) | HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1017059 | 0.75 | HTR2C (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL1586120 | 0.73 | DRD1 (0.48) | TSHRDRD1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260092053-A1 | KHK INHIBITORS | GILEAD SCIENCES INC (US) | 2026-04-02 | — | — | US | disclosed |
| EP-4681774-A2 | KHK INHIBITORS | Gilead Sciences, Inc. (US) | 2026-01-21 | — | — | EP | disclosed |
| EP-4313967-B1 | KHK INHIBITORS | GILEAD SCIENCES INC (US) | 2025-11-12 | — | — | EP | disclosed |
| US-12410160-B2 | KHK inhibitors | GILEAD SCIENCES, INC. (US) | 2025-09-09 | — | — | US | disclosed |
| US-20250152588-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2025-05-15 | — | — | US | disclosed |
| CN-118239926-A | TLR7 and 8 inhibitors, preparation method and application thereof | 上海深势唯思科技有限责任公司 | 2024-06-25 | — | — | CN | disclosed |
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | VERNALIS (R&D) LTD (GB) | 2024-05-09 | — | — | US | disclosed |
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| EP-4277892-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | Les Laboratoires Servier (FR) | 2023-11-22 | — | — | EP | disclosed |
| US-5610303-A | MONOAMIDE OXIDASE INHIBITORS | UBE INDUSTRIES, LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| EP-0664291-A1 | PYRIMIDINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 1995-07-26 | — | — | EP | disclosed |
| EP-0194161-B1 | Cyclopenta[d]pyrimidine derivatives, their preparation and use | SANKYO CO (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-4749704-A | Cyclopenta[d]pyrimidine derivatives and use as antidepressants | SANKYO COMPANY LIMITED (JP) | 1988-06-07 | — | — | US | disclosed |
| EP-0194161-A2 | Cyclopenta[d]pyrimidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1986-09-10 | — | — | EP | disclosed |
| EP-0067630-B1 | PYRIMIDINE DERIVATIVES, A PROCESS FOR PREPARING THEM AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1985-05-08 | — | — | EP | disclosed |
| US-4450162-A | Pyrimidine derivatives and a pharmaceutical composition containing them | SANKYO COMPANY, LIMITED (JP) | 1984-05-22 | — | — | US | disclosed |
| US-4435402-A | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY, LIMITED (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0067630-A1 | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-22 | — | — | EP | disclosed |
| EP-0057440-A1 | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | BCL2, BAX, BCL2A1 | TSHR 2897/4885DRD1 3039/4885HTR2A 2445/4885 |
| US-20260092053-A1 | KHK INHIBITORS | KHK, SLC5A2, HK1 | TSHR 2641/4885DRD1 2047/4885HTR2A 1602/4885 |
| US-12410160-B2 | KHK inhibitors | KHK, KHDRBS1, NADK | TSHR 3789/4885DRD1 4634/4885HTR2A 2802/4885 |
| US-20250152588-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT1S1 | TSHR 4108/4885DRD1 3853/4885HTR2A 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.