Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 7/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30666837 | 1.00 | TSHR (0.37) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL19827177 | 0.98 | TSHR (0.36) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL929527 | 0.98 | TSHR (0.36) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL15428812 | 0.98 | TSHR (0.36) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL14922866 | 0.98 | TSHR (0.36) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL191834 | 0.95 | TSHR (0.37) | TSHRMAPK1NSD2SMN1; SMN2OPRK1 | |
| SCHEMBL14394512 | 0.83 | TSHR (0.32) | TSHROPRK1POLBRXFP1 | |
| SCHEMBL1013730 | 0.77 | HTR2C (0.38) | HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL1017059 | 0.75 | HTR2C (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL9433900 | 0.73 | TSHR (0.37) | TSHRMAPK1ACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | VERNALIS (R&D) LTD (GB) | 2024-05-09 | — | — | US | disclosed |
| EP-4277892-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | Les Laboratoires Servier (FR) | 2023-11-22 | — | — | EP | disclosed |
| CN-116940552-A | Spirocyclic hexane derivatives, pharmaceutical compositions containing them and their use as anti-apoptotic inhibitors | 法国施维雅药厂 | 2023-10-24 | — | — | CN | disclosed |
| US-20230128765-A1 | Small Molecule Activators of Parkin Enzyme Function | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230128765-A1 | Small Molecule Activators of Parkin Enzyme Function | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2023-04-27 | — | — | US | disclosed |
| WO-2022152705-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2022-07-21 | — | — | WO | disclosed |
| US-10844044-B2 | WDR5 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2020-11-24 | — | — | US | disclosed |
| US-20200102288-A1 | WDR5 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2020-04-02 | — | — | US | disclosed |
| US-20190169158-A1 | Small Molecule Activators of Parkin Enzyme Function | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2019-06-06 | — | — | US | disclosed |
| WO-2018023029-A1 | SMALL MOLECULE ACTIVATORS OF PARKIN ENZYME FUNCTION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2018-02-01 | — | — | WO | disclosed |
| EP-0719259-A1 | SUBSTITUTED PYRIDINES AND PYRIMIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1996-07-03 | — | — | EP | disclosed |
| WO-1996013487-A1 | HETEROCYCLYLAMINO AND HETEROCYCLYLOXY-CYCLOALKENYL DERIVATIVES AND THEIR USE AS PEST-CONTROL AGENTS AND FUNGICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1996-05-09 | — | — | WO | disclosed |
| WO-1995007894-A1 | SUBSTITUTED PYRIDINES AND PYRIMIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS PESTICIDES AND FUNGICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1995-03-23 | — | — | WO | disclosed |
| EP-0631575-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS PESTICIDES | Hoechst Schering AgrEvo GmbH (DE) | 1995-01-04 | — | — | EP | disclosed |
| EP-0605552-A1 | SUBSTITUED 4-ALKOXYPYRIMIDINES, A PROCESS FOR PREPARING THE SAME, AGENTS CONTAINING THE SAME AND THEIR USE AS PEST CONTROL AGENTS | Hoechst Schering AgrEvo GmbH (DE) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993019050-A1 | SUBSTITUTED PYRIMIDINES AND THEIR USE AS PESTICIDES | HOECHST SCHERING AGREVO GMBH (DE) | 1993-09-30 | — | — | WO | disclosed |
| US-5236924-A | Controlling plant diseases | SUMITOMO CHEMICAL CO., LTD. (JP) | 1993-08-17 | — | — | US | disclosed |
| WO-1993006091-A1 | SUBSTITUED 4-ALKOXYPYRIMIDINES, A PROCESS FOR PREPARING THE SAME, AGENTS CONTAINING THE SAME AND THEIR USE AS PEST CONTROL AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-01 | — | — | WO | disclosed |
| EP-0534341-A1 | 4-Alkoxypyrimidin derivatives, process for their preparation, agent containing them and their use as parasiticides | Hoechst Schering AgrEvo GmbH (DE) | 1993-03-31 | — | — | EP | disclosed |
| EP-0467760-A1 | Pyrimidine derivatives, methods for producing them, and fungicides, insecticides and/or acaricides containing them as active ingredient | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150293-A1 | SPIROCYCLOHEXANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS ANTI-APOPTOTIC INHIBITORS | BCL2, BAX, BCL2A1 | TSHR 2897/4885MAPK1 1157/4885NSD2 4271/4885 |
| US-20200102288-A1 | WDR5 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | TSHR 4680/4885MAPK1 2694/4885NSD2 512/4885 |
| US-20190169158-A1 | Small Molecule Activators of Parkin Enzyme Function | UCHL1, ADRM1, UCHL5 | TSHR 4431/4885MAPK1 2440/4885NSD2 3664/4885 |
| US-20230128765-A1 | Small Molecule Activators of Parkin Enzyme Function | UCHL1, ADRM1, UCHL5 | TSHR 4474/4885MAPK1 2444/4885NSD2 3663/4885 |
| US-10844044-B2 | WDR5 inhibitors and modulators | WDR5, WDR1, WDR3 | TSHR 4681/4885MAPK1 2555/4885NSD2 490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.