Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.47 |
| ▸ | NPC1 | O15118 | 14/20 | 0.47 |
| ▸ | MEN1 | O00255 | 14/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.47 |
| ▸ | CASP3 | P42574 | 4/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 4/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.43 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190602 | 0.89 | NPC1 (0.58) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL190433 | 0.89 | RAB9A (0.55) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL191394 | 0.85 | RAB9A (0.58) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL190426 | 0.84 | KCNN1 (0.61) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL191689 | 0.81 | GCK (0.52) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL191008 | 0.79 | GCK (0.46) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL192191 | 0.79 | GCK (0.47) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL191295 | 0.78 | GCK (0.49) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL190863 | 0.78 | GCK (0.49) | RAB9ANPC1MEN1KMT2ACASP3 | |
| SCHEMBL191148 | 0.77 | GCK (0.46) | RAB9ANPC1MEN1KMT2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | GCKR, GCK, GALK1 | RAB9A 1808/4885NPC1 1862/4885MEN1 3595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.