Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 13/20 | 0.39 |
| ▸ | CNR1 | P21554 | 11/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19184890 | 0.99 | CNR2 (0.38) | CNR2CNR1LOXLOXL2KDM4E | |
| SCHEMBL19184862 | 0.82 | CNR1 (0.39) | CNR2CNR1PPARGPPARA | |
| SCHEMBL19184867 | 0.78 | MEN1 (0.38) | CNR2CNR1KDM4E | |
| SCHEMBL25454051 | 0.77 | LOX (0.41) | CNR2CNR1LOXLOXL2KDM4E | |
| SCHEMBL10263563 | 0.76 | CYP2D6 (0.47) | LOXLOXL2CYP3A4CCR1CCR5 | |
| SCHEMBL17471315 | 0.75 | LOX (0.46) | LOXLOXL2KDM4ECCR1CCR5 | |
| SCHEMBL22375314 | 0.75 | CNR2 (0.39) | CNR2CNR1LOXLOXL2KDM4E | |
| SCHEMBL18995657 | 0.74 | KDM4E (0.39) | CNR2CNR1KDM4EALOX15TSHR | |
| SCHEMBL26326739 | 0.71 | LOX (0.42) | CNR2CNR1LOXLOXL2 | |
| SCHEMBL12093512 | 0.70 | LOX (0.52) | LOXLOXL2TP53CYP3A4CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718825-B2 | N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals | SANOFI (FR) | 2017-08-01 | — | — | US | disclosed |