Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14666992 | 0.86 | APP (0.49) | APPCCNE1CDK2CDK5NPC1 | |
| SCHEMBL16541503 | 0.84 | APP (0.55) | APPNPC1EGFRPOLBNR2F2 | |
| SCHEMBL14666993 | 0.75 | PRMT5 (0.38) | TDP1LMNATP53 | |
| SCHEMBL5622343 | 0.74 | VNN1 (0.59) | APPNPC1EGFRPOLBNR2F2 | |
| SCHEMBL11973260 | 0.74 | EGFR (0.51) | APPNPC1EGFRPOLBNR2F2 | |
| SCHEMBL14670848 | 0.72 | PRMT5 (0.38) | TDP1NPC1LMNATP53 | |
| SCHEMBL30996045 | 0.72 | MAPT (0.62) | NPC1EGLN1LMNATP53 | |
| SCHEMBL15900574 | 0.71 | NPC1 (0.58) | APPCCNE1CDK2TDP1NPC1 | |
| SCHEMBL84029 | 0.70 | CLK4 (0.57) | TDP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL5823848 | 0.70 | APP (0.60) | APPEGFRPOLBNR2F2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718815-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-08-01 | — | — | US | disclosed |