Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 16/20 | 0.73 |
| ▸ | UBA3 | Q8TBC4 | 16/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | ATG7 | O95352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283822 | 0.85 | NAE1 (0.53) | NAE1UBA3SLC6A4 | |
| SCHEMBL783945 | 0.84 | NAE1 (1.00) | NAE1UBA3ATG7 | |
| SCHEMBL10283376 | 0.72 | NAE1 (0.44) | NAE1UBA3 | |
| SCHEMBL15007501 | 0.72 | NAE1 (0.66) | NAE1UBA3SLC6A2HTR2AHTR2C | |
| SCHEMBL15007500 | 0.72 | NAE1 (0.66) | NAE1UBA3SLC6A2HTR2AHTR2C | |
| SCHEMBL783582 | 0.69 | NAE1 (0.75) | NAE1UBA3 | |
| SCHEMBL12452302 | 0.69 | NAE1 (0.61) | NAE1UBA3 | |
| SCHEMBL12451873 | 0.69 | NAE1 (0.81) | NAE1UBA3ATG7 | |
| SCHEMBL9597999 | 0.68 | ALOX5 (0.46) | NAE1UBA3SLC6A2HTR2AHTR2C | |
| SCHEMBL782316 | 0.64 | NAE1 (0.80) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718788-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-08-01 | — | — | US | disclosed |